Lithium Orotate For Mental Wellness

What Is Lithium Orotate?

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Mental Health and Well Being

Few things are as important as your mental well-being. If your mood is off or you experience a lot of stressful moments, you may notice a slow down with your energy and outlook on life. Lithium is a naturally occurring, essential trace mineral with a long, proven history of therapeutic use for supporting a healthy mood and overall mental wellness. Combining it with orotic acid creates Lithium Orotate — specialized nutrition that support a happy mood, healthy stress response, and normal cognitive function


Healthy Response to Stress

Stress can make you feel fatigued, unmotivated, and down. Lithium Orotate positively supports normal brain chemistry to promote a feeling of confident relaxation. Stop feeling on edge and start feeling what it means to be calm and collected.

Sharpens Focus & Concentration

Maintaining consistent focus in a fast-paced world can be challenging. When demands pile up, it can be overwhelming and hard to stay on task. Lithium orotate helps support your brain’s receptors and neurotransmitters so you can focus on the important things in life.

Encourages a Healthy Outlook

Life is full of ups and downs. Sometimes the lows can make you feel discouraged about the future. The neuron-stimulating effects of Lithium Orotate can help you feel better equipped to deal with life’s extremes.

Lithium Orotate Also Supports:

* Lyme’s Disease
* Low white blood cell counts
* Juvenile convulsive disease
* Alcoholism and liver disorders
* Pain associated with migraine and cluster headaches
* Hyperthyroidism and other thyroid diseases: Studies show that it may even distribution of iodine.
* Post-Traumatic Stress Disorder (PTSD), as well as a general stress reducer.
* Attention Deficit Hyperactivity Disorder (ADHD) and Attention Deficit Disorder (ADD) and aggression: Studies show that individuals taking it experienced lowered levels of rage and anger, as well as improved memory.
* Alzheimer’s disease and dementia

In the reduction of myopia (nearsightedness) and glaucoma: Dr. Hans Nieper found that glaucoma patients could benefit from the dehydrating effect of lithium on the eye, offering patients vision improvement and a lowering of intraocular pressure.
Bipolar disorder: Orotates may lessen effects of manic or depressive episodes and has shown to serve as an effective mood balancer in 70-80 percent of bipolar patients.
Depression: the therapeutic dosage of LO is 150 mg/day. This is compared to 900-1800 mg of the prescription forms. There are no adverse side effects and no need for monitoring blood serum.


Top 10 Benefits of Lithium Orotate

1. Low-dose lithium orotate boosts cognitive function

Lithium orotate(5266-20-6) has been proved to be neuroprotective and to boost cognitive function. Lithium seems to increase BDNF (brain-derived neurotrophic factor) and this is essential in maintaining proper brain function.

Lithium orotate also has the ability to suppress the action of glycogen synthase kinase-3 that is involved in intracellular signaling. Lithium orotate supplement also inhibits calcium-dependent stimulation of pro-apoptotic signaling pathways. This means that it helps to reduce the rate of cell death.

2. Boosting the Immune System

If you develop a superior immune system, your body is able to protect itself from external attacks from possibly harmful organisms. This assists to keep you protected against diseases. Lithium boosts the immune system and provides strong defense against some kinds of harmful organisms.

The ability of Lithium orotate to boost the immune system results from its ability to lower the production of prostaglandins. Prostaglandins are compounds which cause systemic swelling and redness in the body.

3. Relieves Headaches

By promoting a calm and peaceful mind, lithium orotate does not only lower stress, but it also assist in relieving occasional headaches. One research suggests that lithium orotate have unparalleled efficiency for several types of occasional headaches.

4. Promotes Longevity and Anti-Aging

As people age, we all encounter some kind of cognitive impairment. In simpler terms, your memory may worsen, or you may experience confusion feelings. Although common and normal, you may take some steps to maintain your brain healthy as you grow older. Since lithium orotate is also an antioxidant, having in mind that it assists in counteracting free radical’s effects in the brain and body, lithium may promote longevity and induce anti-aging effects.

5. Lithium orotate reduces inflammation

Lowering inflammation in your body is one of the best things you can do to your health. Today, we encounter more environmental assaults, toxins, and foods, which increase inflammation levels and cause diseases. Research shows that lithium orotate lowers inflammatory proteins and raises the amount of anti-inflammatory proteins.

In one scientific study, lithium orotate seemed to show neuroprotective effects against the autoimmunity of the nervous system.

6. Enhances Bone Health

Research suggests that supplementation with lithium enhances and preserves bone mass. Lithium also lowers the risk of bone fractures. Lithium orotate is also believed to assist in cartilage and bone healing.

7. Treatment of Alcoholism

During a scientific study, 42 alcoholic addicts were treated with Lithium during alcoholism rehabilitation in a clinical setting for 6 months. Data was collected from the records of clinical practice for ten years after the initial study. Patients were treated with 150 mg of Lithium Orotate per day for 6 months along with essential phospholipids, magnesium orotate, calcium orotate, and bromelain. Among the patients, ten had no relapse from three to ten years. Thirteen patients were able to stay sober from one to three years. The other patients relapsed between six to 12 months. The scientists concluded that Lithium Orotate therapy was effective and safe in treating alcoholism with minor adverse side effects.

8. Lithium reduces suicidal rates

In 1990, scientists decided to investigate the different amounts of lithium in the drinking water in 27 different Texas counties. They found out that counties which had the least amount of lithium in their drinking water had higher levels of suicidal rates. Counties that had the highest levels of lithium had 40 percent fewer suicidal rates!

A similar study was carried out in Japan in 2013. The study also realized that higher amounts of lithium in drinking water showed a significantly higher protective effect against suicidal risks in women.


9. Sleep

Based on various preliminary cell and animal studies, some researchers have found out that lithium may show some notable positive effects on the body’s “master clock” or circadian rhythm which assists in regulation of digestion, sleep and other crucial daily processes and activities.

Particularly, lithium has been shown to make the circadian rhythm period longer. May help in the treatment of some sleep problems and other issues that may arise when the so called circadian rhythm is “desynchronized” from its usual 24-hour cycle. Some researchers are also investigating whether lithium orotate may assist in the activation of various proteins and genes which are involved in sleep-wake cycle. This cycle assists the body to stay “in sync” with day/night cycles. In other words, this could point to the ability of lithium in making your brain and body more sensitive to biological cues in a day. Some clinical studies have shown that lithium drugs may enhance sleep in bipolar patients. Notwithstanding, this suggestion relates only to “high-dose” medicinal forms of lithium.

10. Neuroprotection

Lithium orotate prevents apoptosis, boosts brain gray matter, boosts DNA replication for neurogenesis, increases NAA (N-acetyl-aspartate), suppresses beta-amyloid secretion. It also protects against brain cell damage once they are formed. The compound also protects against glutamate toxicity. All these actions contribute to neuroprotection and prevention against various brain associated illnesses.

Lithium orotate ADHD

Some clinical studies shows that lithium orotate may lower impulsive-aggressive behaviors linked to ADHD. However, scientists recommended that lithium prescription should only be given after other drugs have failed to work.

Lithium orotate weight loss

Though use of lithium orotate may lead to a decline in appetite, there is no enough clinical evidence to prove that lithium may be used to aid in weight loss.

What Is The Difference Between Lithium Orotate And Lithium

As mentioned earlier, Lithium orotate is a compound which is made up of an alkali metal known as lithium and orotic acid (a substance which is naturally produced in the body). In simpler terms, lithium orotate is a combination of lithium and orotic acid. On the other hand, Lithium is simply an alkali metal and the active ingredient since orotic acid is only used as a transporter molecule that enables lithium to work.


Which Foods Contain Lithium Orotate?

Lithium is a light highly reactive metal found naturally in very low amounts throughout our bodies. It is also available as a supplement and is normally found in drinking water and in several foods such as meat, fish, cereals, nuts, mushrooms, dairy, vegetables, kelp, mustard, and pistachios. However if you want to have a great lithium orotate experience, you should consider buying an over-the-counter supplement which contains the right amount of lithium orotate.

How Long Does Lithium Orotate Take To Work?

Some people may ask, does lithium orotate work right away? The answer is no. It normally takes a few weeks for lithium orotate to start working. Your health care professional will carry out blood tests during the treatment. This is because lithium orotate may affect how well your thyroid or kidney function. It also functions best if the drug level in your body is maintained at a constant level.

Lithium Orotate Drug Interactions

Also, lithium orotate may interact with various medications including MAOIs (monoamine oxidase inhibitors), ACE inhibitors, methyldopa, anticonvulsants, meperidine, antidepressants, loop diuretics, calcium channel blockers, and dextromethorphan.

Lithium Orotate and Alzheimers/Dementia/Parkinsons:

Potential Lithium Orotate Benefits & Uses (incl. for Anxiety):

If you wish to purchase Lithium Orotate Supplements I found several brands at Amazon


Balon R. Possible dangers of a “nutritional supplement” lithium orotate. Ann Clin Psychiatry. 2013;25(1):71.23376874 Barkins R. Low-dose lithium and its health supporting effects. Nutr Perspect. 2016;39(3):32-34.
Smith DF (April 1976). “Lithium orotate, carbonate, and chloride: pharmacokinetics, polydipsia and polyuria in rats”. British Journal of Pharmacology. 56 (4): 399–402.
Wilson, Edward N. (2020). “NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats”. J Alzheimers Dis. 73 (2): 723–

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